When we last left this story, Clomid Cycle #1 had been a bust, but Dr. M (my gyno) was pretty sure I had ovulated. She didn't want to tweak my med dosages or anything - just repeat at 50mg of Clomid and continue with the Metformin at 500mg twice a day. No biggie.
Cycle Day (cd) 1 of the second cycle fell on cd34 of the first cycle, so I felt pretty sure that I was ovulating later along in the cycle rather than on the "average" cd14. My period was normal-to-heavy in terms of flow - surely this cycle would "mean something" because here we were, already starting off better than the first cycle with its "is it or isn't it?" level of flow. I again took the Clomid on cd3 through cd7. This time, since I thought I was ovulating later along, we postponed the baby dancing until cd 11, 14 and 17.
I went for the progesterone check on cd21.
So much for think that this cycle might be The One.
Progesterone clocked in at a WHOPPING 1.something-or-other.
One-point-too-damn-low.
One-point-ain't-gonna-happen-this-month.
One-point-stupid-f-ing-ovaries.
One-point-let's-make-an-appointment-and-figure-this-out.
One-point-let's-try-again.
I had very light spotting on cd25 though 30. Waaaayyy too light to ever be considered a period. Lighter than that whole "is it or isn't it?" flow that led into the first Clomid cycle.
On cd46, we had an appointment with Dr. M to figure out what in the world was going on. And also to discuss having Mr. Lost tested. Because scheduled baby dancing is not fun, and it's even less fun when you don't know if you're even in the appropriate magic window in time. Here's the rundown of that conversation:
{Thank God I messaged some close friends about the appointment shortly after it happened so I can relay all the info here. And this is (one of the reasons) why I keep this blog - so I can remember everything that's happened on the journey.}
- She prescribed 10 days worth of Provera to jump-start a period.
- She kept me on the 50mg dose of Clomid rather than increase because she thinks that I did respond well in January with the 1st cycle. She thinks that I probably did ovulate, but that timing or other factors just didn't make for success (success = positive preg test).
- She's adding Prometrium (progesterone) on cd14 - 23 to ensure that my uterine lining is thick enough for implantation. That's a picture of it to the right. Little pink balls. She said it's possible that egg and sperm met in January, but that the low progesterone number meant that my lining wasn't thick enough for implantation.
- She ordered up a round of blood work to check my insulin and glucose in order to make sure the 1000mg of Metformin is enough. She doesn't want to bump it up because she doesn't want to make me suffer the side effects if I don't need to.
- She ordered up a semen analysis for Mr. Lost. He is less than thrilled about this, but realizes it is necessary. I just want to make sure that we aren't wasting our time - if something is wrong with him, nothing we do with Clomid or anything else is going to make a difference. She said that if Mr. Lost's results are abnormal, we'll be moving on to a specialist - a reproductive endocrinologist. If his results are OK, we'll see how the 3rd cycle goes. If my progesterone is still not right, or if we don't get pregnant, we'll be seeing the specialist.
I asked about more testing . monitoring to try to pinpoint or at least narrow down when ovulation is occurring, but that isn't really her thing. She doesn't specialize in infertility, so she doesn't do that sort of thing.
I explained that we have friends who have gone through this infertility thing and then wound up at adoption, and that from what we've heard, certain agencies won't adopt if a parent is over 40. She hadn't heard that, which surprised me, but at least it gave her some understanding on our timing and desire to be more efficient / aggressive. Medically speaking, 37 for Mr. Lost and 31 for me are perfectly fine ages to make a baby so it isn't so much the biological clocks that are ticking the loudest here.
The next post will reveal the results of all that testing and talk about where we stand right now, which is in the middle of Cycle #3.
Hey, thanks for stopping by my blog! I'm following along on your journey! I know all too well the Clomid not ovulating-but-sometimes-ovulating-game. My progesterone numbers have been all over the place for a long time, no matter what I take. My old OB thought it was just a progesterone issue..come to find out it's estrogen too :) Hoping you get some answers soon!
ReplyDeleteAnd this is why I'm so glad to be moving on to the specialist - my OB/GYN means well and is good for regular gyno stuff, but this infertility thing is clearly not her specialty. There's clearly so much more testing and / or monitoring that could be done. I'm itching to get to that level of care.
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How Clomid Works.
ReplyDeleteAn orally administrated medicine for treatment of infertility in women, Clomid (Clomiphene citrate USP tablet) is a non-sterodial, ovalatry stimulant. This medicine has a great success rate of treating women with infertility caused due to anovulation is designated pharmacologically as 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy] triethylamine citrate (1:1). This medicine has a chemical formula of C26H28ClNO • C6H8O7 and 598.09 amu molecular weight. Generic Clomiphene can get easily soluble in methanol and in ethanol, where as partially soluble in acetone, chloroform and water, is white to pale yellow in color. This medicine is odorless.
Branded as Clomid, generic Clomiphene is a combination of two geometric isomers. Each tablet of Clomid contains Clomiphene 50mg as active molecule and corn starch, lactose, magnesium stearate, pre-gelatinized cornctarch and sucrose as in-active compounds.
With proper care and dose management, Clomid, a pharmacologic potential medicine has shown high rates of success while treating anovulatory patients desiring pregnancy. When a patient starts a dose of Clomid 50mg, the active compound Clomiphene starts a series of endocrine event with tissues containing estrogen receptor culminating in a pre-ovulatory gonadotropin resulting in succeeding follicular rupture. As the endocrine series starts release of pituitary gonadotropins increases, which further initiates steroidogenesis and folliculogenesis. This whole process results in growth of the ovarian follicle and increasing and decreasing level of estradiol and pro-gesterone same as it happens in a normal ovulatory cycle.
The two geometric isomers of Clomiphene citrate, cis zuclomiphene and trans enclomiphene has estrogenic and anti-estrogenic properties.
Clomid belongs to the family of drugs called ovulatory agents. The drug is used to treat fertility problem in women. Fertility in some women is hindered because of lack of proper ovulation. The drug helps in making ovulation possible in the proper manner. The active ingredient of the drug is Clomiphene. Read more http://www.pillsfind.com/clomifene-citrate
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